International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 6 Issue 3
2015 (July - September)
SYNTHESIS, SPECTRAL CHARACTERIZATION AND EVALUATION OF INVITRO ANTIBACTERIAL ACTIVITY OF ISONICOTINOYL HYDRAZONES BEARING PYRIDINE MOIETY
Isonicotinoyl and nicotinoyl hydrazones bearing pyridine moiety have been synthesized by simple condensation reaction between carbonyl compounds(1-3) viz. 2-formyl pyridine, 2-acetylpyridine, 2- benzoylpyridine and isonicotinic acid hydrazide (4)/nicotinic acid hydrazide(5). All the hydrazones are thoroughly characterized by IR, lessThan sup greaterThan 1 lessThan /sup greaterThan H- NMR and mass spectral data. Syntheses of these compounds are further confirmed by mass spectrometry. All the compounds (6-11) were screened for their anti-bacterial activities against lessThan i greaterThan Staphylococcus aureus, lessThan /i greaterThan lessThan i greaterThan Bacillus subtilis, Escherichia coli lessThan /i greaterThan and lessThan i greaterThan Salmonella typhi lessThan /i greaterThan . Isonicotinoyl hydrazones show more antibacterial activity than the corresponding nicotinoyl hydrazones. Substituent groups -H, -CH lessThan sub greaterThan 3 lessThan /sub greaterThan and C lessThan sub greaterThan 6 lessThan /sub greaterThan H lessThan sub greaterThan 5 lessThan /sub greaterThan groups of azomethine carbon are varied. The hydrazones having a methyl group attached to azomethine carbon atom show more pronounced activity.
B. MOKSHARAGNI, KANDERI DILEEP KUMAR, S. CHANDRASEKHAR AND K. HUSSAIN REDDY
Synthesis, characterization, isonicotinoyl and nicotinoylhydrazones, antibacterial activity.
11-18