International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 5 Issue 4
2014 (October - December)
IN-SILICO SCRUTINY AND MOLECULAR DOCKING ANALYSIS FOR BETA SECRETASE-1 AND PRESENILIN-1
We have performed comparative scrutiny between the canonical and non-canonical isoforms of beta secretase-1 and presenilin-1 by various bioinformatics tools for understanding the disparities existent among them. Conjointly, the PDB structure of these neural proteins were docked with two therapeutic drugs (bexarotene and hesperidin) and a toxin (streptozotocin). Results lessThan b greaterThan : lessThan /b greaterThan lessThan i greaterThan In-silico lessThan /i greaterThan scrutiny revealed consanguinity among beta secretase-1 isoforms. On the contrary, amongst presenilin-1 isoforms significant disparities were observed. Molecular docking predicted ubieties of bexarotene, hesperidin and streptozotocin binding sites on beta secretase-1 and presenilin-1. Conclusion lessThan b greaterThan : lessThan /b greaterThan The study propounds pernicious effect of streptozotocin on essential neural proteins and therapeutic potential of bexarotene and hesperidin in Alzheimer's disease and other neurodegenerative disorders. Additionally, the study raises a strong need for evaluation of functionalities of non-canonical isoforms of beta secretase-1 and presenilin-1, in order to uncover their roles in the pathogenesis of Alzheimer's disease and other neurodegenerative disorders.
SHUBHRA CHANDRA , SAPNA KHOWAL AND SAIMA WAJID
Alzheimer’s disease; Beta secretase-1; Presenilin-1; Bexarotene; Hesperidin; Streptozotocin
274-292