International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 5 Issue 4
2014 (October - December)
STUDIES ON 5-CYANOURACILS: EXPEDIENT SYNTHETIC PROTOCOL FOR SYNTHESIS OF NOVEL PYRIDO[2,3-d]PYRIMIDINE AND PYRIMIDO [4,5-d]PYRIMIDINE ANALOGS WITH POTENTIAL PHARMACOLOGICAL ACTIVITY
Novel, diverse pyrido [2,3-d] pyrimidine and pyrimido [4,5-d] pyrimidine analogs were synthesized by the reaction of 1,3-substituted-5-cyano uracil derivatives with appropriate nucleophile under mild conditions. Utilising 5-cyano uracil with various substitutions as a substrate leads to rapid synthesis of annulated uracils with diverse biological properties.
YOGESH Y. PEDGAONKAR, ARUNDHATI C. LELE, NUTAN H. PALSULE DESAI AND MARIAM S. DEGANI
Cyanouracils, pyrido[2,3-d]pyrimidine, pyrimido[4,5-d]pyrimidine, multicomponent.
422-439