International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 5 Issue 3
2014 (July- September)
CORRELATION OF LIPID PEROXIDE -MALONDIALDEHYDE LEVEL WITH DURATION OF DIABETES MELLITUS (TYPE 2)
Type 2 diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and oxidative stress which occurs as a result of imbalance between pro-oxidants and antioxidants. Malondialdehyde (MDA) is a product of the peroxidation and it is considered to be one of the markers of oxidative stress. The association between DM duration and MDA levels in type 2 DM remains controversial. This study was undertaken to evaluate the correlation between MDA levels and DM duration. To compare the oxidative stress in two study groups MDA levels were compared. The mean MDA levels were high in diabetics with duration more than 5 years. The same was compared between the two study groups (Group I-Duration of DM lessThan 5 years & Group II-Duration of DM greaterThan 5 years) using student t test. The difference in MDA levels between two diabetic groups was significant (P
DR.A.J.MANJULA DEVI, DR.S.SRIDEVI , DR.SHANTHI.B AND DR.RATHIROOPAVATHY
Diabetes mellitus , MDA – Malondialdehyde , TBA - Thiobarbituric acid ALE - Advanced Lipoxidation End products , AGE - Advanced Glycation End products
264-270