International Journal of Pharma and Bio Sciences
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editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 4 Issue 4
2013 (October - December)
A NOVEL RP-HPLC METHOD FOR THE QUANTIFICATION OF RIVAROXABAN IN FORMULATIONS
A simple, precise and accurate RP-HPLC method was developed and validated for assay of Rivaroxaban in tablet dosage form. Isocratic elution at a flow rate of 1ml/min was employed on a Kromasil C18 (250x4.6mm, 5µm in particle size) at ambient temperature. The mobile phase consisted of Methanol: Acetonitrile 80: 20 v/v, (P lessThan sup greaterThan H lessThan /sup greaterThan 4.4). The UV detection wavelength was 273 nm and 20µl sample was injected. The retention time for Rivaroxaban was 5.35 min. The percentage RSD for precision and accuracy of the developed method was found to be less than 2%. The newly developed method was validated as per the ICH guidelines. The method was successfully applied for regular analysis of Rivaroxabanin in different formulations and bulk drug.
DR. NALLAGATLA. VIJAYA BHASKAR RAO AND BRC SEKHAR REDDY
Rivaroxaban, RP-HPLC, UV detection, recovery, precise, 273nm.
756-764