International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 4 Issue 1
2013 (January - March)
ANTIULCER ACTIVITY OF POLYHERBAL FORMULATION
The lesion of peptic ulcer disease is a disruption in the mucosal layer of the stomach or duodenum. Recent researchers have discovered a number of newer risk factors regulating the development of disease which are not addressed properly by the current clinical therapies. In this study polyherbal formulation was prepared consisting of lessThan i greaterThan Glycyrrhiza glabra lessThan /i greaterThan , lessThan i greaterThan Garcinia cambogia lessThan /i greaterThan , deglycyrrhizinated licorice extract and lessThan i greaterThan Azadirachta indica lessThan /i greaterThan . Suitable extracts depending on effective chemical composition was prepared and studied on four antiulcer models, namely Naproxen induced ulcers, Histamine induced ulcers, Cysteamine induced ulcers and Ethanol induced ulcer models. This polyherbal formulation significantly reduces ulcer index and ulcer area and shows protection index around 80%, the formulation also shows good antioxidant activity. All results show that polyherbal formulation show gastric healing property by multiple mechanisms. These entire drugs target specific etiological and pathological step which take part in development of ulcers.
A.P PUROHIT AND RICHA KUSHWAHA
Peptic Ulcer, offensive factors, Glycyrrhiza glabra, Azadirachta indica , Garcinia cambogia,deglycyrrhizinated licorice extract .
604-611