International Journal of Pharma and Bio Sciences
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editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 1 Issue 1
2010 (January - March)
Novel Co-Processed Superdisintegrants in the Design of Fast Dissolving Tablets
In the present study, novel co-processed superdisintegrants were developed by solvent evaporation method using crospovidone and sodium starch glycolate in different ratios (1:1, 1:2 & 1:3) for use in the fast dissolving tablet formulations. The developed excipients were evaluated for angle of repose, Carr's index and Hausner's ratio in comparison with physical mixture of superdisintegrants. The angle of repose of the developed excipients was found to be lessThan 25 lessThan sup greaterThan o lessThan /sup greaterThan , Carr's index in the range of 10-15% and Hausner's ratio in the range of 1.13-1.16. Fast dissolving tablets of metoclopramide hydrochloride were prepared using the above co-processed superdisintegrants and evaluated for pre-compression and post-compression parameters. Based on lessThan i greaterThan in vitro lessThan /i greaterThan dispersion time (approximately 19 sec), promising formulation CP lessThan sub greaterThan 1 lessThan /sub greaterThan was tested for lessThan i greaterThan in vitro lessThan /i greaterThan drug release pattern in pH 6.8 Phosphate buffer, short-term stability (at 40 lessThan sup greaterThan 0 lessThan /sup greaterThan C/75% RH for 3 months) and drug excipient interaction (IR spectroscopy). Among the designed formulations, the formulation (CP lessThan sub greaterThan 1 lessThan /sub greaterThan ) containing 4% w/w of co-processed superdisintegrant (1:1 mixture of crospovidone and sodium starch glycolate) emerged as the overall best formulation (t lessThan sub greaterThan 50% lessThan /sub greaterThan 1.30 min) based on drug release characteristics in pH 6.8 phosphate buffer compared to commercial conventional tablet formulation (t lessThan sub greaterThan 50% lessThan /sub greaterThan 6 min). Short-term stability studies on promising formulation indicated that there were no significant changes in drug content and lessThan i greaterThan in vitro lessThan /i greaterThan dispersion time (p lessThan 0.05).
S. B. Shirsand, R. G. Ramani and P. V. Swamy
co-processed superdisintegrants, metoclopramide hydrochloride, fast dissolving tablets, sodium starch glycolate, crospovidone.
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